September 29 - 30, 2011 | Wisconsin Institutes for Discovery | Town Center


 

DAY 1: Thursday, September 29, 2011

Time

Presentations and Speakers

12:30 – 3:00 p.m.

Registration Table Open

Sign up for Friday box lunches ($10 at the registration table)


1:00 – 1:15 p.m.

Day 1 Welcome Remarks

Rock Mackie, Director, Medical Devices Area, Morgridge Institute for Research


1:15 – 2:30 p.m.

Scientific Modeling Overview
This introductory session presents both mathematical and bioscience perspectives on modeling, and how they need to interact to advance scientific knowledge.

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John Yin
Professor of Chemical and Biological Engineering and Systems Biology Theme Leader, Wisconsin Institute for Discovery, UW–Madison

Michael Ferris
Professor of Computer Sciences and Optimization Theme Leader, Wisconsin Institute for Discovery, UW–Madison


2:30 3:30 p.m.

Short Talks: Current Research Projects Advanced by Modeling
A series of presentations by UW–Madison faculty members will showcase research in different bioscience fields—all enabled by modeling approaches specifically suited to project goals.


Moderator: Marisa Otegui
Associate Professor of Botany and Faculty Affiliate, Laboratory of Cell and Molecular Biology, UW–Madison


Speakers and Topics:

Fariba Assadi-Porter
Senior Scientist and Principal Investigator, Dept. of Biochemistry, UW–Madison
"Metabolome Dynamics Platform (MDP): A Novel Method to Portray Metabolic Pathways for Early Disease Detection"


Warren Porter
Professor, Dept. of Zoology; Professor of Environmental Toxicology; and Invited Affiliate Faculty Member, Dept. of Engineering Physics, UW–Madison
"Integrating Momentum, Heat and Mass Balances in Leatherback Sea Turtles: Body Size and Oceanic Distribution Consequences under Climate Change"

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Sarah Duenwald-Kuehl
Research Associate, Dept. of Orthopedics and Rehabilitation, UW–Madison
"Mathematical Modeling of Tissue Damage and Healing Using FFT and Fractal Analyses"


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Jennifer Reed
Assistant Professor, Dept. of Chemical and Biological Engineering, UW–Madison
“In Silico Design of Metabolic Networks”

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Pamela Kreeger
Assistant Professor, Dept. of Biomedical Engineering, UW–Madison
"Multivariate Modeling to Predict Drug Sensitivity in Ovarian Cancer"


3:30 – 3:45 p.m. Break

3:45 – 4:45 p.m.

Triad Panel 1: Radiation Modeling in Engineering Medicine

Moderator: Carol Hirschmugl
Professor of Physics, UW-Milwaukee and Honorary Fellow, Laboratory for Optical and Computational Instrumentation (LOCI), UW–Madison


Panelists:

Rock Mackie
Director, Medical Devices Area, Morgridge Institute for Research

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Soren Bentzen
Program Leader, Imaging and Radiation Science Program, UW Carbone Cancer Center and Professor of Human Oncology, Medical Physics, Biostatistics & Medical Informatics, UWSMPH

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Robert Jeraj
Associate Professor of Medical Physics, UWSMPH

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4:45 – 5:00 p.m.

Poster Session Highlights
A preview of select posters in the poster session that follows.

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Moderator: Brenda Ogle
Assistant Professor, Dept. of Biomedical Engineering, UW–Madison


5:00 – 6:00 p.m Poster Session and Sponsor Tables
Located in the first-floor atrium

5:00 – 6:00 p.m

Reception
Located in the first-floor atrium and H.F. DeLuca Forum

Reception sponsored by the Morgridge Institute for Research


6:00 – 7:00 p.m.

Evening Keynote Address: "A Spectrum of Modeling Approaches for a Spectrum of Cell Biological Studies"

Doug Lauffenburger
Ford Professor of Bioengineering and Professor, Depts. of Biological Engineering, Chemical Engineering and Biology, Massachusetts Institute of Technology

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Introduced by: Sangtae Kim
Executive Director, Morgridge Institute for Research

Keynote sponsored by: Morgridge Institute for Research




DAY 2: Friday, September 30, 2011

Time

Presentations and Speakers


8:30 – 8:40 a.m. Day 2 Welcome Remarks

Ariel Fernandez
Distinguished Investigator, Morgridge Institute for Research

8:40 – 9:30 a.m.

Morning Keynote Address: "An Example of Mathematical Modeling in Biology - The Patterning of Butterflies"

Andy Wathen
Reader in Numerical Analysis, Oxford University Mathematical Institute, UK and Sub-Warden of New College


Introduced by: Amos Ron
Professor, Depts. of Computer Sciences and Mathematics, UW–Madison


Keynote sponsored by: Prairie Technologies


9:30 10:30 a.m.

Short Talks: Research Needs in Search of Modeling Solutions
UW–Madison faculty members will present large-scale research problems that require modeling schemes or mathematical tools to clarify and organize data and findings.


Moderator: Julie C. Mitchell
Associate Professor, Depts. of Mathematics and Biochemistry, UW–Madison


Speakers and Topics:

Anna Huttenlocher
Professor of Pediatrics, Medical Microbiology and Immunology, UW–Madison
“Imaging Leukocyte Migration in Vivo”

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Laurence Loewe
Assistant Professor, Laboratory of Genetics and Wisconsin Institute for Discovery Systems Biology theme, UW–Madison
"Evolutionary Systems Biology and Distributions of Mutational Effects"

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Kurt Squire
Creative Director, Morgridge Institute for Research Education Research Integration Area and Associate Professor, Dept. of Curriculum and Instruction, UW–Madison
“Transforming Public Participation in Science With Technology”

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Randolph S. Ashton
Assistant Professor, Dept. of Biomedical Engineering, UW–Madison and Wisconsin Institute for Discovery BIONATES theme
"A High-Throughput Platform for Investigating the Quantitative, Qualitative and Temporal Cues of the Stem Cell Niche.”

Jon Audhya
Assistant Professor, Dept. of Biomolecular Chemistry, UW–Madison
"Mechanisms of Vesicle Scission"

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10:30 – 10:45 a.m.
Break

10:45 11:45 a.m.

Triad Panel 2: Real Time Problem Solving – Modeling of Breast Cancer


Moderator: Lee Gravatt Wilke
Associate Professor, Dept. of Surgery and Director, University of Wisconsin Health Breast Center, UW Health/UW School of Medicine and Public Health


Panelists:

Patricia Keely
Professor, Dept. of Cell and Regenerative Biology, UW–Madison

Alissa Weaver
Associate Professor, Dept. of Cancer Biology, Vanderbilt University Medical Center

Yi Jiang
Technical Staff Member, Theoretical Division, Los Alamos National Laboratory and Associate Professor, Dept. of Mathematics & Statistics, Georgia State University

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11:45 a.m. – 1:00 p.m.
Lunch
Attendees may order a $10 box lunch at Thursday's registration table; eat at Wisconsin Institutes for Discovery restaurants; or go to Union South or nearby eateries. Lunch is not provided as part of the MathBio3 format.

1:00 – 2:00 p.m.

Resource Panel: Careers in Scientific Modeling
What are the job market and career pathways for scientific modeling expertise? What funding sources could help you integreate modeling approaches into cutting-edge research? This resource panel will provide answers.


Moderator: Wendy Crone
Professor, Dept. of Engineering Physics and Interim Associate Dean, Graduate School, UW–Madison


Panelists:

Andy Wathen
Reader in Numerical Analysis, Oxford University Mathematical Institute, UK and Sub-Warden of New College

Doug Lauffenburger
Ford Professor of Bioengineering and Professor, Depts. of Biological Engineering, Chemical Engineering and Biology, Massachusetts Institute of Technology

Curtis Rueden
Software Architect, UW–Madison Laboratory for Optical and Computational Instrumentation (LOCI)

Yi Jiang
Technical Staff Member, Theoretical Division, Los Alamos National Laboratory and Associate Professor, Dept. of Mathematics & Statistics, Georgia State University

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2:00 – 3:00 p.m.

Afternoon Keynote Address: "Monte Carlo Simulation of Light Transport in Biological Tissues

Steven L. Jacques
Professor, Depts. of Dermatology and Biomedical Engineering, Oregon Health & Science University

Introduced by: Sangtae Kim
Executive Director, Morgridge Institute for Research

Keynote sponsored by: Prairie Technologies

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3:00 – 4:00 p.m.

Short Talks: Effective Tools for Scientific Modeling
Presentations by UW–Madison and affiliated experts will identify a range of modeling approaches, including mathematical tools, which can be used to accelerate and explain scientific research.


Moderator: Miron Livny
Chief Technology Officer, Morgridge Institute for Research and Professor, Dept. of Computer Sciences, UW–Madison


Speakers and Topics:

Dan Negrut
Associate Professor, Nvidia CUDA Fellow, Dept. of Mechanical Engineering, UW–Madison
"HCT: A Heterogeneous Computing Template for Dynamical System Simulation in Engineering"

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Sushmita Roy
Postdoctoral Fellow, Broad Institute, Harvard and MIT and Assistant Professor, Dept. of Biostatistics and Medical Informatics, UW–Madison and Wisconsin Institute for Discovery (starting Jan 2012)
"Comparative Inference of Regulatory Programs of Stress Response"


Dave Anderson
Assistant Professor, Dept. of Mathematics, UW–Madison
"The Computational Benefits of Using Random Time Change Representations for Stochastically Modeled Biochemical Reaction Networks"

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Mark Craven
Professor, Dept. of Biostatistics and Medical Informatics, UW–Madison,
“Identifying Candidate Pathways to Explain Phenotypes in Genome-Wide Mutant Screens”


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James B. Rawlings
Professor, Dept. of Chemical and Biological Engineering, UW–Madison
"Scientific Computing and Reproducible Computational Research Using GNU Octave"


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4:00 – 4:15 p.m.

Wrap of Sessions: Lessons Learned


The wrap-up will summarize key themes of the symposium and provide an overview of further resources for scientific modeling, including recommended funding sources.

Kevin Eliceiri
Director, Laboratory for Optical and Computational Instrumentation (LOCI)