September 29 - 30, 2011 | Wisconsin Institutes for Discovery | Town Center
Speaker and Moderator Bios
David F. Anderson
David F. Anderson is an assistant professor in the department of mathematics at UW–Madison. He is currently doing research on “Stochastic and deterministic models of intracellular reaction networks: analysis and algorithms.”
Anderson received his M.A (2001) and Ph.D. (2005) in mathematics from Duke University. He received a B.A. in mathematics from the University of Virginia, Charlottesville, Va. He was recognized as a University Housing Honored Instructor, UW–Madison (2010); won a Burroughs Wellcome Fund Career Award at the Scientific Interface (2008); earned the L.P. and Barbara Smith Award for Teaching Excellence, Duke University Mathematics Department (2004); secured National Science Foundation VIGRE grant support (Fall 2000 - Spring 2005); and won the E.J. McShane prize in Mathematics, University of Virginia Mathematics Department (May 2000).
Randolph S. Ashton
Randolph S. Ashton was classically educated as a chemical engineer earning his B.S. from Hampton University in 2002 and Ph.D. from Rensselaer Polytechnic Institute in 2007 with Professor Ravindra Kane. At R.P.I., Ashton trained as a NIH-NIGMS biomolecular science and engineering fellow, allowing him to apply his engineering background to the interdisciplinary field of regenerative medicine, a research direction that he further pursued while performing postdoctoral studies at the University of California Berkeley’s Stem Cell Center with Professor David Schaffer as a California Institute for Regenerative Medicine and an NIH postdoctoral fellow.
Currently, Ashton is appointed as an assistant professor in the Bio-nanocomposite Scaffolds for Tissue Engineering (BIONATES) theme at the Wisconsin Institute for Discovery and in the department of biomedical engineering at the University of Wisconsin–Madison. His research interests center around understanding how to control stem cell fate using rationally engineered biomimetic systems and molecules with an emphasis on elucidating the microenvironmental factors that regulate the development and maintenance of the central nervous system.
Fariba M. Assadi-Porter
Fariba M. Assadi-Porter is a senior scientist and principal investigator (NMR facility and department of biochemistry) at UW–Madison. She is also an invited honorary fellow in the UW–Madison department of zoology. In addition, Assadi-Porter is a co-founder of Isomark, a Madison-based medical device company.
Her current funded research includes projects such as multimodal retinal functional imaging; biochemical and computational analysis for detection of early diabetic retinopathies; the sweet protein brazzein and its interaction with the human taste receptor; and a comparative study of the anti-inflammatory effects of c9, t11-conjugated linoleic acid and the cyclooxygenase-2 inhibitor Celecoxib in a mouse model of arthritis.
Assadi-Porter received a B.S. in chemistry and a Ph.D. in biomolecular chemistry from UW–Madison.
Anjon Audhya is an assistant professor in the department of biomolecular chemistry at the University of Wisconsin School of Medicine and Public Health. He was previously a lecturer at the University of California, San Diego (Biomedical Sciences Graduate Program). He has 35 publications covering a range of 4-kinase, protein and cellular function, and genomics topics. He currently is a recipient of the March of Dimes Basil O’Connor Starter Scholar Research Award; American Heart Association Scientist Development Grant Award; and Shaw Scientist Award, Greater Milwaukee Foundation.
Audhya earned a B.S. in biochemistry from Brown University, a Ph.D. in biomedical sciences from the University of California, San Diego, and did his postdoctoral work in biochemistry and cell biology at the Ludwig Institute for Cancer Research, La Jolla, Calif.
Søren M. Bentzen
Søren M. Bentzen is a professor of human oncology and program leader of the Imaging and Radiation Science Program at the Carbone Comprehensive Cancer Center at the University of Wisconsin School of Medicine and Public Health, Madison, Wis. Bentzen holds joint appointments as a professor of medical physics and of biostatistics & medical informatics at UW–Madison. He earned his M.Sc. (physics and mathematics, 1981), Ph.D. (medical imaging, 1986) and D.Sc. (clinical radiobiology, 1994) from Aarhus University, Denmark.
Bentzen has published more than 340 papers and presented more than 270 invited lectures. He currently serves on nine international cancer journal editorial boards and was recently elected member of the International Commission on Radiation Units and Measurements (ICRU). His research has been recognized by 20 awards and honors including the ESTRO Breuer Gold Medal (2003), the MD Anderson Distinguished Alumnus Award (2008), Honorary Life Memberships of Association of Radiation Oncologists of India (2008) and Belgian Society for Therapeutic Radiology and Oncology (2009). He was selected as presenter of the 2011 Douglas Lea Lecture of the UK Institute of Physics and Engineering in Medicine. Benzten held an Honorary Professorship at University College London (2000–2005). He is currently the Varian Visiting Professor to the Radiation Therapy Oncology Group (RTOG) and Adjunct Professor of Radiobiology and Medical Physics, University of Copenhagen.
Benzten has served at the MD Anderson Cancer Center (1987-1988), Danish Cancer Society/Aarhus University (1988-1997), Gray Laboratory/Mount Vernon Hospital, London (1998-2004) and UW School of Medicine and Public Health (2005–present). His main research interests are bioeffect modeling of clinical outcomes in radiation oncology, late effects of radiotherapy, integration of data from genomics, proteomics and molecular imaging into novel radiation therapy strategies and evidence-based medicine.
Mark Craven is a professor in the department of biostatistics and medical informatics, with an affiliate appointment in the department of computer sciences at the University of Wisconsin–Madison. He is the bioinformatics leader at the UW Institute for Clinical and Translational Research, a member of the UW Carbone Cancer Center and an affiliate of the Genome Center of Wisconsin. His research interests are situated at the intersection of machine learning, natural language processing and biomedical informatics.
The focus of his research program is to develop and apply machine learning and NLP methods to the problems of inferring models of, and reasoning about, networks of interactions among genes, proteins, environmental factors and diseases. Current projects in his group are focused on (i) automatically extracting gene-regulation events from the biomedical literature, (ii) uncovering the intracellular networks involved in host-virus interactions, (iii) learning models to assess risk for post-hospitalization deep venous thrombosis using genetic and clinical data, (iv) classifying molecular profiles for toxicological applications and (v) identifying gene-regulatory elements and interactions in prokaryotes
Wendy C. Crone
Professor Wendy C. Crone’s research is in the area of solid mechanics, and many of the topics she has investigated are connected with nanotechnology and biotechnology. As a professor in the department of engineering physics with affiliate appointments in the departments of biomedical engineering and materials science and engineering at the University of Wisconsin–Madison, she has applied her technical expertise to improving fundamental understanding of mechanical response of materials, enhancing material behavior through surface modification and nanostructuring, exploring the interplay between cells and the mechanics of their surroundings, and developing new material applications and medical devices. She has worked in the medical device industry and has publications and patents pending on medical devices and biomaterials.
As a sample of prior accomplishments, her research group has demonstrated the capability of shape memory alloy-based thermomechanical data storage device at the nanoscale, adapted plasma surface modifications techniques to produce highly biocompatible shape memory alloys, developed magnetic methods for control over the position and orientation of nanowires and conducted foundational experiments on the mechanical behavior of responsive hydrogels.
Crone was granted a CAREER Award by the National Science Foundation in 2002, received the top Hot Talk/Cool Paper Award from the Materials Research Society in 2007, was honored with the WEPAN Educator Award in 2011 and received a Career Enhancement Award for Stem Cell Research (K18) from the National Institutes of Health in 2011. In addition to more than 50 peer-reviewed journal publications, she is the author of the book Survive and Thrive: A Guide for Untenured Faculty (Morgan & Claypool Publishers, 2010). Crone also holds the position of Interim Associate Dean for Physical Sciences in the Graduate School of the University of Wisconsin–Madison.
Sarah Duenwald-Kuehl obtained her bachelor’s degree in biomedical engineering from the University of Minnesota before coming to the University of Wisconsin for her M.S. and Ph.D. in the same field under the advisement of Rod Lakes and Ray Vanderby. Her thesis research focused on the characterization of connective tissue viscoelasticity through experiment and modeling, novel approaches to characterizing tendon and ligament damage and noninvasive measurement of connective tissue mechanics using ultrasound.
Duenwald-Kuehl now works as a research associate in Vanderby’s lab, expanding on the field of acoustoelasticity, which uses ultrasound to detect mechanical changes in tissues.
Kevin Eliceiri received his undergraduate and graduate training in microbiology and biotechnology at UW–Madison. His graduate research was developing imaging approaches for the model nematode C. elegans. He received further postgraduate training at the National Integrated Microscopy Resource (Madison, Wis.) in the area of computer science and microscopy. Since 2000 he has been at the Laboratory for Optical and Computational Instrumentation (LOCI) at UW–Madison. He is currently director of the LOCI and a principal investigator in the Laboratory of Molecular Biology at the UW–Madison Graduate School.
Eliceiri also is an affiliate investigator of biomedical engineering and medical physics at the Morgridge Institute for Research. His current research focuses on the development of novel optical imaging methods for investigating cell signaling and cancer progression, and the development of software for multidimensional image analysis. Eliceiri is a principal investigator of the ImageJDev project and co-principaI investigator of the Open Microscopy Environment Consortium.
Distinguished investigator Ariel Fernández is a physical chemist formally trained as a mathematician. He is the inventor of target wrapping, a molecular binding mode and filter that promises to radically improve a wide variety of medical therapies. He brings his pioneering work in this exciting drug discovery technology to the Morgridge Institute, where as leader of the Fernández Lab he will continue developing methods to generate more stable, effective and safer pharmaceutical compounds.
Fernández, an Argentinean-American, earned a Ph.D. in chemical physics at Yale University in 1984, and most recently held the Karl F. Hasselmann Chaired Professorship of Bioengineering at Rice University. His research spans various areas of algebra (representation theory), physical chemistry, physics and most recently, molecular evolution and drug discovery.
Michael C. Ferris
Michael C. Ferris is a professor of computer sciences and leads the Optimization Group within the Wisconsin Institute for Discovery at UW–Madison. He received his Ph.D. from the University of Cambridge, England, in 1989.
Ferris' research is concerned with algorithmic and interface development for large scale problems in mathematical programming, including links to the GAMS and AMPL modeling languages, and general
purpose software such as PATH, NLPEC and EMP. He has worked on several applications of both optimization and complementarity, including cancer treatment plan development, radiation therapy,
video-on-demand data delivery, economic and traffic equilibria, structural and mechanical engineering.
Ferris received the Beale-Orchard-Hays prize from the Mathematical Programming Society and is a past recipient of a NSF Presidential Young Investigator Award and a Guggenheim Fellowship. He serves as
co-editor of Mathematical Programming, and is on the editorial boards of the SIAM Journal on Optimization, Transactions of Mathematical Software and Optimization Methods and Software.
Anna Huttenlocher trained at Harvard Medical School, Boston Children's Hospital and the University of California-San Francisco. She then moved to the University of Illinois-Champaign and soon became involved with the Illinois M.D./Ph.D. program. Dr. Huttenlocher joined the faculty of UW–Madison in 1999 with a joint appointment in the departments of pediatrics and pharmacology and has been associate director of the Medical Scientist Training Program since that time.
In 2006, she moved her basic science appointment to medical microbiology and immunology. Dr. Huttenlocher is a practicing pediatric rheumatologist. She is recognized internationally for her pioneering studies of cell migration and alterations of cell migration in human diseases.
Steven L. Jacques
Steven L. Jacques received a B.S. in biology at MIT, and both an M.S. in electrical engineering and computer science and a Ph.D. in biophysics and medical physics from the University of California-Berkeley (1984), where he used dielectric microwave measurements to explore the in vivo distribution of water in the stratum corneum of human skin.
His postdoctoral work was at the Wellman Center for Photomedicine at Massachusetts General Hospital, rising to the position of lecturer in dermatology/bioengineering, Harvard Medical School. He studied laser effects in skin, both experimental and theoretical. His team developed the use of Monte Carlo computer simulations to study optical transport in biological tissues, which is now widely used in the field of biophotonics.
In 1988, he joined the University of Texas M. D. Anderson Cancer as an assistant professor of urology/biophysics and established a laboratory developing novel laser and optical methods for medicine, later achieving a tenured position as associate professor. He developed a hand-held spectrometer and the analysis software to noninvasively measure hyperbilirubinemia in newborns. This device was patented, licensed and FDA approved to replace heel stick tests, and is now practiced in neonatal care. As of 2009, over 20 million newborns have been tested with the device.
In 1996, Jacques moved to Oregon and joined the Oregon Health and Science University, where he now serves as professor of dermatology and biomedical engineering. His work continues on developing novel uses of optical technologies for both therapy and diagnosis. Currently, he has developed a hand-held polarized light camera to visualize skin cancer margins and guide surgical excision, now in clinical trials. He has developed in vivo sub-nm measurements of vibration of the cochlear membrane of the inner ear in animal models. He currently is developing novel microscopes that are sensitive to the ultrastructure of cells and tissues. Jacques has authored more than 100 papers in peer-reviewed journals.
Robert Jeraj is an associate professor of medical physics, radiology, human oncology and biomedical engineering at UW–Madison. He has a broad background in medical physics, with specific training and expertise in key research areas for this application. In particular, he has an extensive research experience in the use of molecular imaging for treatment assessment and use of novel imaging in drug development.
Jeraj leads the UW Image Response Assessment Team (IRAT) and co-directs the UW Image Analysis Center (IMAC). He is also the co-leader of the UW Translational Imaging Research Group (TIR) that oversees concept development, protocol design and implementation in trials incorporating novel anti-cancer drugs with imaging endpoints. Among other duties, he is chair of the Imaging for Treatment Assessment working group at AAPM, a member of the Medical Physics committee at RTOG and a member of the Experimental Imaging Sciences Committee at ACRIN.
Jeraj received a B.Sc. and a Ph.D. in physics from the University of Ljubljana, Slovenia. He did postdoctoral studies in medical physics at UW–Madison.
Patricia J. Keely
Patricia J. Keely is an associate professor in the department of pharmacology; director of the Molecular and Cellular Pharmacology Graduate Program in the School of Medicine and Public Health; and an affiliate of the department of bioengineering at UW–Madison. She also is affiliated with the UW–Madison Laboratory of Molecular Biology, and is Co-PI of the UW–Madison Laboratory for Optical and Computational Instrumentation.
Keely received her Ph.D. in cell and developmental biology from the University of Minnesota, and completed postdoctoral training at Washington University in St. Louis and the University of North Carolina–Chapel Hill. She has been investigating aspects of cellular interaction with extracellular matrix since a graduate student.
Currently, researchers in Keely’s laboratory are investigating the interaction of breast tumor cells with the extracellular matrix. In particular, they seek to understand the changes in collagen structure and organization that accompany and may contribute to tumor progression, and how cells respond to those changes including cell invasion and migration through 3-D matrices and in vivo, and integrin and Rho signaling pathways linked to mechanical signaling. The lab utilizes animal and culture models and multiphoton, SHG and fluorescent lifetime imaging approaches to assist in these goals.
Pamela Kreeger is an assistant professor in the department of biomedical engineering at UW–Madison. She earned a B.S. in chemistry from Valparaiso University, a Ph.D. in chemical engineering from Northwestern University and did a postdoctoral fellowship in biological engineering at MIT. She has been an assistant professor in BME since Jan 2009, and her research uses systems biology and tissue engineering methods to study diseases in women's health.
Douglas A. Lauffenburger
Douglas A. Lauffenburger is the Ford Professor of Bioengineering and head of the department of biological engineering at MIT. Lauffenburger also holds appointments in the departments of biology and chemical engineering; is a member of the Center for Biomedical Engineering, Center for Environmental Health Sciences, Center for Gynepathology Research and Koch Institute for Integrative Cancer Research; and is the director of the Computational & Systems Biology Initiative.
Lauffenburger’s B.S. and Ph.D. are in chemical engineering from the University of Illinois and the University of Minnesota, in 1975 and 1979, respectively. His major research interests are in cell engineering—the fusion of engineering with molecular cell biology. A central focus of his research program is in receptor-mediated cell communication and intracellular signal transduction, with emphasis on development of predictive computational models derived from quantitative experimental studies, for cell cue/signal/response relationships important in pathophysiology with application to drug discovery and development. Lauffenburger has co-authored a monograph entitled Receptors: Models for Binding, Trafficking & Signaling, published by Oxford University Press in 1993; he has also co-edited the book entitled Systems Biomedicine: Concepts and Perspectives, published by Elsevier in 2010. More than 90 doctoral students and postdoctoral associates have completed their training under his supervision or co-supervision.
Lauffenburger has served as a consultant or scientific advisory board member for Astra-Zeneca, Beyond Genomics, CellPro, Complete Genomics, Eli Lilly, Entelos, Genstruct, Insert Therapeutics, Johnson & Johnson, Merrimack Pharmaceuticals, Pfizer, Precision Therapeutics, SyStemix, the Burroughs-Wellcome Fund and the Whitaker Foundation. His awards include the Pierre Galletti Award from AIMBE, the A.P. Colburn Award, Bioengineering Division Award, and W.H. Walker Award from AIChE, the Distinguished Lecture Award from BMES, the C.W. McGraw Award from ASEE, the Amgen Award in Biochemical Engineering from the Engineering Foundation and a J.S. Guggenheim Fellowship, along with a number of named lectures at academic institutions. He is a member of the National Academy of Engineering and of the American Academy of Arts & Sciences, and has served as President of the Biomedical Engineering Society, Chair of the College of Fellows of AIMBE and on the Advisory Council for the National Institute for General Medical Sciences at NIH.
A UW–Madison professor of computer sciences in the College of Letters and Science and director of the UW Center for High Throughput Computing, Miron Livny serves both the Morgridge Institute for Research and the Wisconsin Institute for Discovery by providing the advanced computing tools and infrastructure necessary to facilitate the leading-edge work of scientists in both institutes. Livny, who specializes in distributed computing, continues his work with researchers around the world to advance computer and data intensive science.
Laurence Loewe is currently an assistant professor in the UW–Madison Laboratory of Genetics and the Wisconsin Institute for Discovery. In 2010, he was a visiting assistant professor in the Laboratory of Genetics at UW–Madison.
In 2007, Loewe was a postdoctoral researcher at the Center for Systems Biology Edinburgh, University of Edinburgh, UK. Prior to that, he was in 2006 a lecturer in evolutionary genetics and in 2003 a postdoctoral research fellow, both at the Institute of Evolutionary Biology, University of Edinburgh. He also served as a visiting scientist at the Interdisciplinary Center for Scientific Computing, University of Heidelberg, Germany, in 2003.
Rock Mackie currently is director of the Medical Devices Area at the Morgridge Institute for Research. He was for many years a University of Wisconsin–Madison professor of medical physics at the School of Medicine and Public Health and biomedical engineering in the College of Engineering.
The focus of Mackie’s area at the Morgridge Institute is to explore and build medical devices with the potential to treat or cure serious medical conditions, to improve the movement of new devices from research lab to clinical use and to improve the safety of large medical devices, especially those used in radiation therapy and medical imaging. His area will be the most closely integrated with UW–Madison and in many ways its translational emphasis has been modeled on the successful Coulter Foundation Program at the university’s department of biomedical engineering. The Medical Devices Area includes a facility for rapid prototyping, a technology assessment program and the launch of a medical devices R&D consortium through partnerships with companies and academia.
Mackie was also chairman, co-founder and co-inventor of TomoTherapy Inc. (recently acquired by Accuray), a publicly-traded radiation therapy equipment company based in Madison, Wis.
Julie Mitchell is an associate professor of mathematics and biochemistry at UW–Madison. Before coming to Madison in 2003, she was a postdoc at the University of California-San Diego. Her Ph.D. was in mathematics from UC-Berkeley and her undergraduate degree from San Jose State University. She is originally from San Jose, Calif.
Mitchell's research group studies molecular interactions and deformations at the structural level. This has produced a range of tools for various protein modeling tasks such as protein docking, prediction of binding and allostery hot spots, density-based decomposition of protein motions and homology-based protein deformation models. In addition, her group has produced tools to identify hydrogen bonding patterns on the surface of a protein that allow it to recognize DNA.
Associate Professor Dan Negrut received his mechanical engineering Ph.D. in 1998 from the University of Iowa, working under the supervision of Professor Emeritus Edward J. Haug. He spent six years working for Mechanical Dynamics Inc., a software company in Ann Arbor, Mich. In 2004 he served as an adjunct assistant professor in the department of mathematics at the University of Michigan, Ann Arbor.
He spent 2005 as a visiting scientist at Argonne National Laboratory in the mathematics and computer science division. At the end of 2005 Dan joined the mechanical engineering faculty at the University of Wisconsin–Madison. His interests are in computational science and he leads the Simulation-Based Engineering Lab at Wisconsin. He founded and is the co-director of the Applied Computing Center at the University of Wisconsin–Madison. The sponsors of this center include the National Science Foundation, NVIDIA Corporation, Microsoft Corporation, US Army and several industry partners. Negrut's projects focus on high performance computing, large scale multibody dynamics, uncertainty quantification, numerical integration methods for dynamic systems and fluid-solid interaction.
Negrut received in 2009 a National Science Foundation Career Award. Since 2010 he is an NVIDIA CUDA Fellow.
Brenda Ogle is an assistant professor of biomedical engineering at UW–Madison. She received her Ph.D. in biomedical engineering from the University of Minnesota and was an assistant professor of physiology at the Mayo Clinic from 2004 to 2006. Ogle enjoys teaching applications-based subject matter and as such has taught Mathematics for Engineers, Biomedical Engineering Design, Tissue Engineering and Engineering Extracellular Matrices. Beyond the classroom, Ogle has developed novel technologies to analyze stem cell behavior including multiphoton flow cytometry. She uses this technology to develop means to repair damaged heart muscle. In addition, Ogle has studied cell fusion as a mechanism of stem cell differentiation, development, transfer of viruses and cancer metastasis. She is funded by the National Institutes of Health, the National Science Foundation, the Department of Defense, the American Heart Association and the Coulter Foundation.
Marisa S. Otegui
Marisa S. Otegui is an associate professor in the department of botany and a faculty affiliate of the Laboratory of Cell and Molecular Biology at UW–Madison. Her research program focuses on the regulation of protein and membrane trafficking mechanisms in plant cells. The goal is to understand how cells control the flow of proteins between different cellular compartments. More specifically, this research is interested in understanding the mechanisms that control the sorting of plasma membrane proteins to and from the plasma membrane and how these events affect plant development. Her program has developed different microscopy imaging approaches to visualize protein and membrane trafficking events at high three-dimensional resolution.
Otegui was awarded a Fulbright Program Fellowship and a postdoctoral fellowship at the University of Colorado, Boulder. She completed her postdoctoral training in plant cell biology there in 2004. She earned a B.A. in biology and a Ph.D. in botany from the University of La Plata, Argentina.
Warren P. Porter
Warren P. Porter is a faculty member at UW–Madison, where he is a professor in the department of zoology; professor of environmental toxicology; and invited affiliate faculty member in the department of engineering physics. He received a B.S in zoology from UW–Madison, an M.A. in ichthyology from UCLA, a Ph.D. in physical ecology from UCLA and an NIH postdoctorate in biophysical ecology from Washington University in St. Louis.
Porter has developed additional technical competence in three-dimensional modeling, micrometeorology and microclimatology, chemical engineering, aerodynamics, mathematics and numerical methods (including stochastic modeling processes and mathematics for dynamic modeling), mechanical engineering, remote sensing (satellite imagery), statistics and toxicology. Other technical competencies include computer language programming, graphics packages, numerical methods for fluid dynamics programs, Maya (an animation program for rigid 3-D animal models) and Rhinocerous and Zbrush (morphing programs and conversion of meshes to NURBS format models)
Porter received a Romnes Faculty Fellowship award (1977) for excellence in research and unusual research. He was a Guggenheim fellow from 1979 to 1980. His 1991 paper, "Thermodynamic Equilibria of Animals with Environment," was selected as one of the 40 classic papers in the field of ecology. He is an invited faculty associate in the Center for Integrated Agriculture Systems (1997-present) and was a senior fellow, National Center for Ecosystems Analysis and Synthesis, Santa Barbara, Calif., from 1998 to 1999. He was a member of the science advisory board of the Rodale Institute from 2002 to 2005, and is currently a member of the advisory board of Beyond Pesticides (2000 – present).
James B. Rawlings
James B. Rawlings is a professor in the department of chemical and biological engineering at UW–Madison, and from 2000 to 2003 was the department chair. He previously served as an associate professor in the department of chemical engineering at the University of Texas at Austin.
His research interests include chemical process control; nonlinear model predictive control; state estimation and monitoring; chemical reaction engineering; and virus modeling and stochastic chemical kinetics. Since 1986, he has authored more than 160 journal publications and received numerous awards in the automatic control, process development, and chemical engineering fields. Rawlings is a member of the American Chemical Society (ACS), American Institute of Chemical Engineers (AIChE, fellow), Institute of Electrical and Electronics Engineers (IEEE, senior member) and Society for Industrial and Applied Mathematics (SIAM).
He received a B.S. in chemical engineering from the University of Texas at Austin and a Ph.D. in chemical engineering from UW–Madison. He was a NATO postdoctoral fellow, Institute for System Dynamics and Process Control at the University of Stuttgart, Stuttgart, Germany.
Jennifer Reed is an assistant professor in the department of chemical and biological engineering, UW–Madison (2007-present). Her research group studies bacterial metabolism and regulation through the generation and subsequent analysis of metabolic and regulatory models and their reconciliation with experimental data. It uses computational models and develops methods to study biological systems, engineer cells, and expand our knowledge of the underlying mechanisms behind observed cellular behavior. This group builds, analyzes, and utilizes metabolic and regulatory models of organisms involved in bioremediation, biofuels, and pharmaceutical applications. In addition, it is developing computational methods for designing strains or cell lines with enhanced production yields of desired products. Her group intends to use the developed models to identify novel gene functions or regulatory interactions, further clarifying the roles gene products play within the cell.
Reed received a Ph.D., M.S. and B.S. in bioengineering from the University of California, San Diego.
Sushmita Roy is a computing innovation postdoctoral fellow at the Broad Institute of Harvard and MIT in the labs of Aviv Regev and Manolis Kellis.
She earned a bachelor’s degree in computer engineering from the University of Pune (pronounced poonay), India, and a Ph.D. in computer science from the University of New Mexico.
Roy will be starting as an assistant professor in the department of biostatistics and medical informatics, and in the Systems Biology theme at the Wisconsin Institute of Discovery at UW–Madison.
Curtis Rueden directs software development efforts at the Laboratory for Optical and Computational Instrumentation (LOCI). He is the project lead for the ImageJDev project, co-founder of the Bio-Formats library, long-time contributor to the OME-XML standard and creator of the OME-TIFF file format. He has written several other software packages including VisBio and SLIM Plotter—the ideas from both of which his team is working to incorporate into the next-generation version of ImageJ.
Before joining LOCI, Rueden was a student developer on the VisAD Java Component Library Project at the University of Wisconsin–Madison while completing his B.S. and M.S. in computer sciences.
Kurt Squire is an associate professor of educational communications and technology, co-director of the Games+Learning+Society Initiative, creative director of the Education Research Integration Area (ERIA) of the Wisconsin Institutes for Discovery and vice president of the Learning Games Network, a nonprofit network expanding the role of games and learning.
An internationally recognized leader in digital media in technology, Squire has delivered dozens of invited addresses across Europe, Asia and North America and written more than 50 scholarly articles on digital media and education. His research investigates the potential of digital game-based technologies for systemic change in education.
Squire’s work integrates research and theory on digital media with theories of situated cognition in order to understand how to design educational environments in a digital age. He was recently awarded an NSF CAREER grant to study embedded assessments in online role playing games and a grant from the MacArthur Foundation to study mobile media and learning in youth culture.
Previously, Squire co-directed the Education Arcade, a partnership between higher education and the Entertainment Software Association. He also led the Augmented Reality Gaming Project, a collaborative project with MIT and Harvard University funded by the Department of Education to develop and study augmented reality games for learning which have been used by thousands of students across the U.S. Squire also co-founded Joystick101.org, and for several years wrote a column with Henry Jenkins for Computer Games magazine.
Andy Wathen is a reader in numerical analysis at the Oxford University Mathematical Institute, UK and sub-warden of New College.
His research focuses on scientific computing methods and algorithms associated with the numerical solution of partial differential equations. Applications range from coolant flows to biological patterning. His work, in particular on block preconditioners for saddle-point systems, has impacted on a number of application areas: it has led, for example, to fast solvers for incompressible flow simulation and a significant class of methods of general utility in optimization that emanate from his introduction of ‘constraint preconditioning.’
Dr. Alissa Weaver is an associate professor of cancer biology at Vanderbilt University. She earned her B.S. and B.A. from Stanford University in 1991 and M.D./Ph.D. from the University of Virginia in 1998. Following a postdoctoral fellowship in cell biology and a clinical pathology residency at Washington University in St. Louis, she was recruited to Vanderbilt as an independent faculty member in 2003.
The overall goal of her research is to understand mechanisms of tumor progression. The laboratory has a particular focus on the role of cytoskeletal rearrangements in promoting tumor invasion and metastasis. Current projects in the laboratory include: 1) understanding how actin cytoskeletal rearrangements lead to the formation and function of subcellular structures such as invadopodia and lamellipodia that cancer cells use to invade tissues; 2) the role of the branched actin regulator cortactin in membrane trafficking; 3) role of cortactin in head and neck squamous cell carcinoma (HNSCC) growth aggressiveness; and 4) mechanotransduction-induced invasion signaling.
The Weaver laboratory uses a variety of approaches, including cell biological studies, mouse tumor experiments, bioinformatics, collaborations with computational/mathematical modelers and translational human studies.
Yi Jiang received her Ph.D. in physics from University of Notre Dame. After a postdoctoral fellowship at Los Alamos National Laboratory, she stayed on as a Technical Staff Member in the Theoretical Division. She has very recently taken a leave from LANL and joined Georgia State University.
Jiang's research interest lies at the interface between physics, mathematics and biology. She studies the quantitative mechanisms of biological and biomedical problems. She is interested in developing multiscale theoretical and computational models to understand cell and tissue level organization. In all the projects she works on, she has maintained close ties with experimentalists, which has been both productive and rewarding. Her current main focuses are modeling cancer development and collective motion in bacteria.
John Yin is a professor of chemical and biological engineering and the Systems Biology Theme Leader at the Wisconsin Institute for Discovery, UW–Madison.
Studies in the liberal arts and chemical engineering at Columbia University, along with cello pursuits at the Juilliard School of Music and summer internships at the National Cancer Institute, provided diverse and engaging opportunities for Yin’s intellectual and personal growth during his undergraduate years.
Doctoral work in chemical and biomolecular engineering at UC-Berkeley was followed by postdoctoral research at the Max-Planck Institute for Biophysical Chemistry (Goettingen, Germany). These experiences set the foundation for Yin's academic career, initially as an assistant professor of engineering at Dartmouth College.
In 1998 he moved to UW–Madison where he is now a professor of chemical and biological engineering. Yin has been honored with an Alexander von Humboldt Research Fellowship (Germany), the Young Investigator Award and Presidential Early Career Award for Science and Engineering (PECASE) from the National Science Foundation, and is currently a member of the National Institutes of Health (NIH) Study Section on Modeling and Analysis of Biological Systems.
In 2009 Yin was named theme leader of systems biology at the Wisconsin Institutes for Discovery, a public-private venture at the University of Wisconsin–Madison, aiming to advance discovery at the interfaces between bio-, info- and nano-technologies. Yin's research interests are in systems biology, pre-biotic chemistry and virus-host interactions.